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An accurate strategy for pointing the key biocatalytic sites of bre2691A protein for modification of the brevilaterin from Brevibacillus laterosporus

BACKGROUND: Brevilaterin A-E, a novel class of multi-component cationic antimicrobial lipopeptides, were biosynthesized by a non-ribosomal peptides synthetase (NRPS) in Brevibacillus laterosporus. However, the antimicrobial abilities of different brevilaterin components varied greatly, and this mult...

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Detalles Bibliográficos
Autores principales: Han, Panpan, Chen, Zhou, Liu, Yangliu, Ma, Aijin, Li, Siting, Jia, Yingmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484153/
https://www.ncbi.nlm.nih.gov/pubmed/36123650
http://dx.doi.org/10.1186/s12934-022-01918-x