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Exploring optimal Taxol® CYP725A4 activity in Saccharomyces cerevisiae
BACKGROUND: CYP725A4 catalyses the conversion of the first Taxol® precursor, taxadiene, to taxadiene-5α-ol (T5α-ol) and a range of other mono- and di-hydroxylated side products (oxygenated taxanes). Initially known to undergo a radical rebound mechanism, the recent studies have revealed that an inte...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484169/ https://www.ncbi.nlm.nih.gov/pubmed/36123694 http://dx.doi.org/10.1186/s12934-022-01922-1 |