Effects of a recombinant humanized anti‐cocaine monoclonal antibody on the metabolism and distribution of cocaine in vitro and in mice

The anti‐cocaine monoclonal antibody, h2E2, is a candidate for treating cocaine‐use disorder. h2E2 binds to and sequesters cocaine in the plasma compartment, effectively decreasing cocaine concentrations in the brains of rats and mice. Despite the binding of cocaine to h2E2, plasma cocaine concentra...

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Detalles Bibliográficos
Autores principales: Turner, Mackenzie E., Wetzel, Hanna N., Zinani, Dakota B., Crutchfield, Christopher A., Norman, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Invited Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484263/
https://www.ncbi.nlm.nih.gov/pubmed/36121122
http://dx.doi.org/10.1002/prp2.1009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484263/
https://www.ncbi.nlm.nih.gov/pubmed/36121122
http://dx.doi.org/10.1002/prp2.1009

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