CXCR2 inhibition enables NASH-HCC immunotherapy

OBJECTIVE: Hepatocellular carcinoma (HCC) is increasingly associated with non-alcoholic steatohepatitis (NASH). HCC immunotherapy offers great promise; however, recent data suggests NASH-HCC may be less sensitive to conventional immune checkpoint inhibition (ICI). We hypothesised that targeting neut...

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Detalles Bibliográficos
Autores principales: Leslie, Jack, Mackey, John B G, Jamieson, Thomas, Ramon-Gil, Erik, Drake, Thomas M, Fercoq, Frédéric, Clark, William, Gilroy, Kathryn, Hedley, Ann, Nixon, Colin, Luli, Saimir, Laszczewska, Maja, Pinyol, Roser, Esteban-Fabró, Roger, Willoughby, Catherine E, Haber, Philipp K, Andreu-Oller, Carmen, Rahbari, Mohammad, Fan, Chaofan, Pfister, Dominik, Raman, Shreya, Wilson, Niall, Müller, Miryam, Collins, Amy, Geh, Daniel, Fuller, Andrew, McDonald, David, Hulme, Gillian, Filby, Andrew, Cortes-Lavaud, Xabier, Mohamed, Noha-Ehssan, Ford, Catriona A, Raffo Iraolagoitia, Ximena L, McFarlane, Amanda J, McCain, Misti V, Ridgway, Rachel A, Roberts, Edward W, Barry, Simon T, Graham, Gerard J, Heikenwälder, Mathias, Reeves, Helen L, Llovet, Josep M, Carlin, Leo M, Bird, Thomas G, Sansom, Owen J, Mann, Derek A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484388/
https://www.ncbi.nlm.nih.gov/pubmed/35477863
http://dx.doi.org/10.1136/gutjnl-2021-326259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484388/
https://www.ncbi.nlm.nih.gov/pubmed/35477863
http://dx.doi.org/10.1136/gutjnl-2021-326259

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