Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B

ATP7B is a human copper-transporting P(1B)-type ATPase that is involved in copper homeostasis and resistance to platinum drugs in cancer cells. ATP7B consists of a copper-transporting core and a regulatory N-terminal tail that contains six metal-binding domains (MBD1-6) connected by linker regions....

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Detalles Bibliográficos
Autores principales: Orädd, Fredrik, Steffen, Jonas Hyld, Gourdon, Pontus, Andersson, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484656/
https://www.ncbi.nlm.nih.gov/pubmed/36070320
http://dx.doi.org/10.1371/journal.pcbi.1010074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484656/
https://www.ncbi.nlm.nih.gov/pubmed/36070320
http://dx.doi.org/10.1371/journal.pcbi.1010074

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