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Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B
ATP7B is a human copper-transporting P(1B)-type ATPase that is involved in copper homeostasis and resistance to platinum drugs in cancer cells. ATP7B consists of a copper-transporting core and a regulatory N-terminal tail that contains six metal-binding domains (MBD1-6) connected by linker regions....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484656/ https://www.ncbi.nlm.nih.gov/pubmed/36070320 http://dx.doi.org/10.1371/journal.pcbi.1010074 |