C/EBPα-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection

PURPOSE: To investigate the function of C/EBPα in the development of aortic dissection (AD) and the underlying mechanism. METHODS: Aortic vascular smooth muscle cells (VSMCs) were isolated, cultured, and identified from AD rats. Then, C/EBPα and PIK3C2A were knockdown or overexpressed by siRNA or pl...

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Detalles Bibliográficos
Autores principales: Lu, Heng, Chen, Yi, Chen, Yinhai, Huang, Lingchen, Chen, Liangwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484969/
https://www.ncbi.nlm.nih.gov/pubmed/36132983
http://dx.doi.org/10.1155/2022/7465353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484969/
https://www.ncbi.nlm.nih.gov/pubmed/36132983
http://dx.doi.org/10.1155/2022/7465353

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