A critique of the hypothesis that CA repeats are primary targets of neuronal MeCP2

The DNA-binding protein MeCP2 is reported to bind methylated cytosine in CG and CA motifs in genomic DNA, but it was recently proposed that arrays of tandemly repeated CA containing either methylated or hydroxymethylated cytosine are the primary targets for MeCP2 binding and function. Here we invest...

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Detalles Bibliográficos
Autores principales: Chhatbar, Kashyap, Connelly, John, Webb, Shaun, Kriaucionis, Skirmantas, Bird, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485053/
https://www.ncbi.nlm.nih.gov/pubmed/36122935
http://dx.doi.org/10.26508/lsa.202201522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485053/
https://www.ncbi.nlm.nih.gov/pubmed/36122935
http://dx.doi.org/10.26508/lsa.202201522

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