Small molecule SJ572946 activates BAK to initiate apoptosis

Poration of the outer mitochondrial membrane by the effector BCL-2 proteins BAK and BAX initiates apoptosis. BH3-only initiators BID and BIM trigger conformational changes in BAK and BAX transforming them from globular dormant proteins to oligomers of the apoptotic pores. Small molecules that can di...

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Detalles Bibliográficos
Autores principales: Sekar, Giridhar, Singh, Geetika, Qin, Xingping, Guibao, Cristina D., Schwam, Brittany, Inde, Zintis, Grace, Christy R., Zhang, Weixing, Slavish, P. Jake, Lin, Wenwei, Chen, Taosheng, Lee, Richard E., Rankovic, Zoran, Sarosiek, Kristopher, Moldoveanu, Tudor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485059/
https://www.ncbi.nlm.nih.gov/pubmed/36147946
http://dx.doi.org/10.1016/j.isci.2022.105064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485059/
https://www.ncbi.nlm.nih.gov/pubmed/36147946
http://dx.doi.org/10.1016/j.isci.2022.105064

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