Cargando…

Small molecule SJ572946 activates BAK to initiate apoptosis

Poration of the outer mitochondrial membrane by the effector BCL-2 proteins BAK and BAX initiates apoptosis. BH3-only initiators BID and BIM trigger conformational changes in BAK and BAX transforming them from globular dormant proteins to oligomers of the apoptotic pores. Small molecules that can di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sekar, Giridhar, Singh, Geetika, Qin, Xingping, Guibao, Cristina D., Schwam, Brittany, Inde, Zintis, Grace, Christy R., Zhang, Weixing, Slavish, P. Jake, Lin, Wenwei, Chen, Taosheng, Lee, Richard E., Rankovic, Zoran, Sarosiek, Kristopher, Moldoveanu, Tudor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485059/ https://www.ncbi.nlm.nih.gov/pubmed/36147946 http://dx.doi.org/10.1016/j.isci.2022.105064

Ejemplares similares

Structural basis of BAK activation in mitochondrial apoptosis initiation
por: Singh, Geetika, et al.
Publicado: (2022)

BID-induced structural changes in BAK promote apoptosis
por: Moldoveanu, Tudor, et al.
Publicado: (2013)

Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis
por: Zheng, Janet H., et al.
Publicado: (2018)

Quantification of drug-induced fractional killing using high-throughput microscopy
por: Inde, Zintis, et al.
Publicado: (2021)

Kinetic Heterogeneity of Cancer Cell Fractional Killing
por: Inde, Zintis, et al.
Publicado: (2020)

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity
por: Inde, Zintis, et al.
Publicado: (2020)

A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay
por: Wu, Qiong, et al.
Publicado: (2021)

Félix Restrepo, S.J. /
por: Cacua Prada, Antonio
Publicado: (1997)

Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis
por: Quarato, Giovanni, et al.
Publicado: (2023)

In situ architecture of Opa1-dependent mitochondrial cristae remodeling
por: Fry, Michelle Y., et al.
Publicado: (2023)

BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking
por: Fallahzadeh-Mamaghami, Vahid, et al.
Publicado: (2023)

Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX
por: Singh, Rumani, et al.
Publicado: (2023)

$D_{sJ}^{(*)}$ Spectroscopy at LHCb
por: Ravina, Baptiste
Publicado: (2015)

Pascual Diaz, S.J., : el arzobispo mártir
por: Correa, Eduardo J.
Publicado: (1945)

Synthesis of Isotopically Labeled, Spin-Isolated Tyrosine and Phenylalanine for Protein NMR Applications
por: Young, Brandon M., et al.
Publicado: (2021)

Microdroplet Sandwich Real-Time RT-PCR for Detection of Pandemic and Seasonal Influenza Subtypes
por: Angione, Stephanie L., et al.
Publicado: (2013)

Playing FullBAK
por: Walensky, Loren D.
Publicado: (2013)

Cancer chemoresistance and BAK
por: Fox, Joanna L.
Publicado: (2015)

Archivo de Ignacio Ellacuría, S.J.
por: Reyes Ramírez, Rocío de los
Publicado: (2002)

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target
por: Iyer, Sweta, et al.
Publicado: (2020)

Francisco Xavier Clavigero, SJ : ilustre universitario constructor de la patria mexicana /
por: Maneiro, Juan Luis, 1744-1802
Publicado: (2004)

Predicting Human Age with Bloodstains by sjTREC Quantification
por: Ou, Xue-ling, et al.
Publicado: (2012)

Bak activators get in the groove
por: Leslie, Mitch
Publicado: (2011)

BAK additive influence on results
por: Shah, Rupali D, et al.
Publicado: (2013)

The great migration of Bax and Bak
por: Edlich, Frank
Publicado: (2015)

BÄK: Zehn-Punkte-Plan
por: Landschek, Ines
Publicado: (2020)

BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove
por: Azad, Abul, et al.
Publicado: (2013)

Ignacio Martin-Baró SJ : la psicología de la liberación como propuesta para los pueblos latinoamericanos /
por: Jardinez Hernández, José Arturo
Publicado: (2006)

Combined IL-12 Plasmid and Recombinant SjGST Enhance the Protective and Anti-pathology Effect of SjGST DNA Vaccine Against Schistosoma japonicum
por: Cheng, Po-Ching, et al.
Publicado: (2016)

Prime-Boost Vaccine Regimen for SjTPI and SjC23 Schistosome Vaccines, Increases Efficacy in Water Buffalo in a Field Trial in China
por: Da'Dara, Akram A., et al.
Publicado: (2019)

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
por: Dai, Haiming, et al.
Publicado: (2011)

Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization
por: Pang, Yuan-Ping, et al.
Publicado: (2012)

Ocular surface disease in patients with glaucoma or ocular hypertension treated with either BAK-preserved latanoprost or BAK-free travoprost
por: Katz, Gregory, et al.
Publicado: (2010)

Larvicidal and anti-termite activities of microbial biosurfactant produced by Enterobacter cloacae SJ2 isolated from marine sponge Clathria sp.
por: Harikrishnan, Sekar, et al.
Publicado: (2023)

Bak apoptotic function is not directly regulated by phosphorylation
por: Tran, V H, et al.
Publicado: (2013)

Eltrombopag directly activates BAK and induces apoptosis
por: Chen, Meng, et al.
Publicado: (2023)

Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK
por: Ke, F, et al.
Publicado: (2015)

Vida del P. Francisco J. Saeta, S.J. : sangre misionera en Sonora
por: Kino, Eusebio Francisco, 1644-1711
Publicado: (1961)

SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicum
por: Liu, Feng, et al.
Publicado: (2008)

Is the anomalous decay ratio of D$_{sJ}$(2632) due to isospin breaking?
por: Maiani, Luciano, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_n70tl8bkrnncduk7kklc3u6jku