Lactococcus lactis engineered to deliver hCAP18 cDNA alleviates DNBS-induced colitis in C57BL/6 mice by promoting IL17A and IL10 cytokine expression

With its antimicrobial and immunomodulating properties, the cathelicidin (LL37) plays an important role in innate immune system. Here, we attempted to alleviate chemically induced colitis using a lactococci strain that either directly expressed the precursor to LL37, hCAP18 (LL-pSEC:hCAP18), or deli...

Descripción completa

Detalles Bibliográficos
Autores principales: Noguès, Esther Borras, Kropp, Camille, Bétemps, Laureline, de Sousa, Cassiana, Chain, Florian, Auger, Sandrine, Azevedo, Vasco, Langella, Philippe, Chatel, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485145/
https://www.ncbi.nlm.nih.gov/pubmed/36123355
http://dx.doi.org/10.1038/s41598-022-19455-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485145/
https://www.ncbi.nlm.nih.gov/pubmed/36123355
http://dx.doi.org/10.1038/s41598-022-19455-3

Ejemplares similares