Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue

In Duchenne muscular dystrophy, dystrophin loss leads to chronic muscle damage, dysregulation of repair, fibro-fatty replacement, and weakness. We develop methodology to efficiently isolate individual nuclei from minute quantities of frozen skeletal muscle, allowing single nuclei sequencing of irrep...

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Detalles Bibliográficos
Autores principales: Scripture-Adams, Deirdre D., Chesmore, Kevin N., Barthélémy, Florian, Wang, Richard T., Nieves-Rodriguez, Shirley, Wang, Derek W., Mokhonova, Ekaterina I., Douine, Emilie D., Wan, Jijun, Little, Isaiah, Rabichow, Laura N., Nelson, Stanley F., Miceli, M. Carrie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485160/
https://www.ncbi.nlm.nih.gov/pubmed/36123393
http://dx.doi.org/10.1038/s42003-022-03938-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485160/
https://www.ncbi.nlm.nih.gov/pubmed/36123393
http://dx.doi.org/10.1038/s42003-022-03938-0

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