Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue

In Duchenne muscular dystrophy, dystrophin loss leads to chronic muscle damage, dysregulation of repair, fibro-fatty replacement, and weakness. We develop methodology to efficiently isolate individual nuclei from minute quantities of frozen skeletal muscle, allowing single nuclei sequencing of irrep...

Descripción completa

Detalles Bibliográficos
Autores principales: Scripture-Adams, Deirdre D., Chesmore, Kevin N., Barthélémy, Florian, Wang, Richard T., Nieves-Rodriguez, Shirley, Wang, Derek W., Mokhonova, Ekaterina I., Douine, Emilie D., Wan, Jijun, Little, Isaiah, Rabichow, Laura N., Nelson, Stanley F., Miceli, M. Carrie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485160/
https://www.ncbi.nlm.nih.gov/pubmed/36123393
http://dx.doi.org/10.1038/s42003-022-03938-0

Ejemplares similares

Ejemplares similares