Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells

Triple-negative breast cancer (TNBC) is a highly aggressive and metastasizing cancer that has the worst prognosis out of all breast cancer subtypes. The epithelial–mesenchymal transition (EMT) and cancer stem cells (CSCs) have been proposed as important mechanisms underlying TNBC metastasis. CDK9 is...

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Detalles Bibliográficos
Autores principales: Cheng, Shasha, Yang, Guan-Jun, Wang, Wanhe, Ma, Dik-Lung, Leung, Chung-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2021
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485199/
https://www.ncbi.nlm.nih.gov/pubmed/36157485
http://dx.doi.org/10.1016/j.gendis.2021.06.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485199/
https://www.ncbi.nlm.nih.gov/pubmed/36157485
http://dx.doi.org/10.1016/j.gendis.2021.06.005

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