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Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) is a highly aggressive and metastasizing cancer that has the worst prognosis out of all breast cancer subtypes. The epithelial–mesenchymal transition (EMT) and cancer stem cells (CSCs) have been proposed as important mechanisms underlying TNBC metastasis. CDK9 is...
Autores principales: | Cheng, Shasha, Yang, Guan-Jun, Wang, Wanhe, Ma, Dik-Lung, Leung, Chung-Hang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chongqing Medical University
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485199/ https://www.ncbi.nlm.nih.gov/pubmed/36157485 http://dx.doi.org/10.1016/j.gendis.2021.06.005 |
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