Endosomal recycling defects link Huntington’s disease with McLeod syndrome

Chhetri and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces mangane...

Descripción completa

Detalles Bibliográficos
Autores principales: Marsan, Elise, Huang, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485561/
https://www.ncbi.nlm.nih.gov/pubmed/36112418
http://dx.doi.org/10.1083/jcb.202208164
Descripción
Sumario:Chhetri and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces manganese transport across cell membrane.

Ejemplares similares