Endosomal recycling defects link Huntington’s disease with McLeod syndrome

Chhetri and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces mangane...

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Detalles Bibliográficos
Autores principales: Marsan, Elise, Huang, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485561/
https://www.ncbi.nlm.nih.gov/pubmed/36112418
http://dx.doi.org/10.1083/jcb.202208164
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author Marsan, Elise
Huang, Eric J.
author_facet Marsan, Elise
Huang, Eric J.
author_sort Marsan, Elise
collection PubMed
description Chhetri and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces manganese transport across cell membrane.
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spelling pubmed-94855612023-03-16 Endosomal recycling defects link Huntington’s disease with McLeod syndrome Marsan, Elise Huang, Eric J. J Cell Biol Spotlight Chhetri and colleagues (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202112073) show that Rab11-mediated endosomal recycling regulates cell surface expression of McLeod syndrome protein XK. Mutant huntingtin interferes with the recycling of XK to the cell surface and significantly reduces manganese transport across cell membrane. Rockefeller University Press 2022-09-16 /pmc/articles/PMC9485561/ /pubmed/36112418 http://dx.doi.org/10.1083/jcb.202208164 Text en © 2022 Marsan and Huang https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Marsan, Elise
Huang, Eric J.
Endosomal recycling defects link Huntington’s disease with McLeod syndrome
title Endosomal recycling defects link Huntington’s disease with McLeod syndrome
title_full Endosomal recycling defects link Huntington’s disease with McLeod syndrome
title_fullStr Endosomal recycling defects link Huntington’s disease with McLeod syndrome
title_full_unstemmed Endosomal recycling defects link Huntington’s disease with McLeod syndrome
title_short Endosomal recycling defects link Huntington’s disease with McLeod syndrome
title_sort endosomal recycling defects link huntington’s disease with mcleod syndrome
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485561/
https://www.ncbi.nlm.nih.gov/pubmed/36112418
http://dx.doi.org/10.1083/jcb.202208164
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