The AIRE G228W mutation disturbs the interaction of AIRE with its partner molecule SIRT1

The autoimmune regulator (AIRE) protein functions as a tetramer, interacting with partner proteins to form the “AIRE complex,” which relieves RNA Pol II stalling in the chromatin of medullary thymic epithelial cells (mTECs). AIRE is the primary mTEC transcriptional controller, promoting the expressi...

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Detalles Bibliográficos
Autores principales: Santos, Jadson C., Dametto, Mariangela, Masson, Ana Paula, Faça, Vitor M., Bonacin, Rodrigo, Donadi, Eduardo A., Passos, Geraldo Aleixo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485725/
https://www.ncbi.nlm.nih.gov/pubmed/36148232
http://dx.doi.org/10.3389/fimmu.2022.948419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485725/
https://www.ncbi.nlm.nih.gov/pubmed/36148232
http://dx.doi.org/10.3389/fimmu.2022.948419

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