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Super-enhancer associated core regulatory circuits mediate susceptibility to retinoic acid in neuroblastoma cells

Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related deaths in children. High-risk tumours are often difficult to treat, and patients’ survival chances are less than 50%. Retinoic acid treatment is part of the maintenance therapy given to neuroblastoma patients; howe...

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Detalles Bibliográficos
Autores principales: Gomez, Roshna Lawrence, Woods, Laura M., Ramachandran, Revathy, Abou Tayoun, Ahmad N., Philpott, Anna, Ali, Fahad R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485839/
https://www.ncbi.nlm.nih.gov/pubmed/36147741
http://dx.doi.org/10.3389/fcell.2022.943924