Detection of innate immune response modulating impurities (IIRMI) in therapeutic peptides and proteins: Impact of excipients

Unintended immunogenicity can affect the safety and efficacy of therapeutic proteins and peptides, so accurate assessments of immunogenicity risk can aid in the selection, development, and regulation of biologics. Product- and process- related impurities can act as adjuvants that activate the local...

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Detalles Bibliográficos
Autores principales: Thacker, Seth G., Her, Cheng, Kelley-Baker, Logan, Ireland, Derek D C., Manangeeswaran, Mohanraj, Pang, Eric S., Verthelyi, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485840/
https://www.ncbi.nlm.nih.gov/pubmed/36148237
http://dx.doi.org/10.3389/fimmu.2022.970499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485840/
https://www.ncbi.nlm.nih.gov/pubmed/36148237
http://dx.doi.org/10.3389/fimmu.2022.970499

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