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Detection of innate immune response modulating impurities (IIRMI) in therapeutic peptides and proteins: Impact of excipients
Unintended immunogenicity can affect the safety and efficacy of therapeutic proteins and peptides, so accurate assessments of immunogenicity risk can aid in the selection, development, and regulation of biologics. Product- and process- related impurities can act as adjuvants that activate the local...
Autores principales: | Thacker, Seth G., Her, Cheng, Kelley-Baker, Logan, Ireland, Derek D C., Manangeeswaran, Mohanraj, Pang, Eric S., Verthelyi, Daniela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485840/ https://www.ncbi.nlm.nih.gov/pubmed/36148237 http://dx.doi.org/10.3389/fimmu.2022.970499 |
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