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GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein

BACKGROUND/OBJECTIVE: GLP-1R agonists have been shown to reduce fasting and postprandial plasma lipids, both of which are independent risk factors for the development of cardiovascular disease. However, how endogenous GLP-1 – which is rapidly degraded – modulates intestinal and hepatic lipid metabol...

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Detalles Bibliográficos
Autores principales: Hoffman, Simon, Alvares, Danielle, Adeli, Khosrow
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486018/
https://www.ncbi.nlm.nih.gov/pubmed/36067913
http://dx.doi.org/10.1016/j.molmet.2022.101590