Development of a UPLC-MS/MS method for the determination of orelabrutinib in rat plasma and its application in pharmacokinetics

The aim of the present study was to establish an ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the determination of orelabrutinib in rat plasma using futibatinib as internal standard (IS), and to apply it for a pharmacokinetic study in rats. Orelabrutinib w...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ya-nan, Hu, Yingying, Wang, Jing, Chen, Chaojie, Cai, Jianping, Xu, Ren-ai, Lu, Zhongqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486086/
https://www.ncbi.nlm.nih.gov/pubmed/36147349
http://dx.doi.org/10.3389/fphar.2022.991281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486086/
https://www.ncbi.nlm.nih.gov/pubmed/36147349
http://dx.doi.org/10.3389/fphar.2022.991281

Ejemplares similares