Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Genetic and preclinical studies have implicated adenylyl cyclase 1 (AC1) as a potential target for the treatment of chronic inflammatory pain. AC1 activity is increased following inflammatory pain stimuli and AC1 knockout mice show a marked reduction in responses to inflammatory pain. Previous drug...

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Detalles Bibliográficos
Autores principales: Dwyer, Tiffany S., O’Brien, Joseph B., Ptak, Christopher P., LaVigne, Justin E., Flaherty, Daniel P., Watts, Val J., Roman, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486168/
https://www.ncbi.nlm.nih.gov/pubmed/36147328
http://dx.doi.org/10.3389/fphar.2022.977742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486168/
https://www.ncbi.nlm.nih.gov/pubmed/36147328
http://dx.doi.org/10.3389/fphar.2022.977742

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