Easily automated radiosynthesis of [(18)F]P10A-1910 and its clinical translation to quantify phosphodiesterase 10A in human brain

Our previous work showed that [(18)F]P10A-1910 was a potential radioligand for use in imaging phosphodiesterase 10A (PDE10A). Specifically, it had high brain penetration and specific binding that was demonstrated in both rodents and non-human primates. Here, we present the first automatic cGMP-level...

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Detalles Bibliográficos
Autores principales: Wei, Huiyi, Wei, Junjie, Zhang, Shaojuan, Dong, Shiliang, Li, Guocong, Ran, Wenqing, Dong, Chenchen, Zhang, Weibin, Che, Chao, Luo, Wenzhao, Xu, Hao, Dong, Zhiyong, Wang, Jinghao, Wang, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486304/
https://www.ncbi.nlm.nih.gov/pubmed/36147528
http://dx.doi.org/10.3389/fbioe.2022.983488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486304/
https://www.ncbi.nlm.nih.gov/pubmed/36147528
http://dx.doi.org/10.3389/fbioe.2022.983488

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