Design, synthesis and cytotoxic evaluation of novel betulonic acid-diazine derivatives as potential antitumor agents

With the purpose to improve antiproliferative activity, 26 new betulonic acid-diazine derivatives were designed and synthesized from betulinic acid. The anticancer activity of these semi-synthetic compounds was evaluated by MTT assay in both tumor cell lines and normal cell line. The results indicat...

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Detalles Bibliográficos
Autores principales: Shu, Yisong, Li, Feifei, Han, Yaotian, Wang, Penglong, Gao, Feng, Yan, Mengmeng, Liang, Miao, Ma, Qiang, Zhang, Yuzhong, Ding, Xia, Lei, Haimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486541/
https://www.ncbi.nlm.nih.gov/pubmed/36147251
http://dx.doi.org/10.3389/fchem.2022.969770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486541/
https://www.ncbi.nlm.nih.gov/pubmed/36147251
http://dx.doi.org/10.3389/fchem.2022.969770

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