Proof-Reading Thioesterase Boosts Activity of Engineered Nonribosomal Peptide Synthetase

[Image: see text] Nonribosomal peptide synthetases (NRPSs) are a vast source of valuable natural products, and re-engineering them is an attractive path toward structurally diversified active compounds. NRPS engineering often requires heterologous expression, which is hindered by the enormous size o...

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Detalles Bibliográficos
Autores principales: Pourmasoumi, Farzaneh, De, Sayantan, Peng, Huiyun, Trottmann, Felix, Hertweck, Christian, Kries, Hajo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486807/
https://www.ncbi.nlm.nih.gov/pubmed/36044980
http://dx.doi.org/10.1021/acschembio.2c00341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486807/
https://www.ncbi.nlm.nih.gov/pubmed/36044980
http://dx.doi.org/10.1021/acschembio.2c00341

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