Protein Conformational Space at the Edge of Allostery: Turning a Nonallosteric Malate Dehydrogenase into an “Allosterized” Enzyme Using Evolution-Guided Punctual Mutations

We unveil the intimate relationship between protein dynamics and allostery by following the trajectories of model proteins in their conformational and sequence spaces. Starting from a nonallosteric hyperthermophilic malate dehydrogenase, we have tracked the role of protein dynamics in the evolution...

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Detalles Bibliográficos
Autores principales: Iorio, Antonio, Brochier-Armanet, Céline, Mas, Caroline, Sterpone, Fabio, Madern, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486893/
https://www.ncbi.nlm.nih.gov/pubmed/36056899
http://dx.doi.org/10.1093/molbev/msac186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486893/
https://www.ncbi.nlm.nih.gov/pubmed/36056899
http://dx.doi.org/10.1093/molbev/msac186

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