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MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8

BACKGROUND: Our previous study identified miR-99a as a negative regulator of early chondrogenic differentiation. However, the functional role of miR-99a in the pathogenesis of osteoarthritis (OA) remains unclear. METHODS: We examined the levels of miR-99a and Frizzled 8 (FZD8) expression in tissue s...

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Detalles Bibliográficos
Autores principales: Wang, Yeyang, Zheng, Xiaoyu, Luo, Dixin, Xu, Wangyang, Zhou, Xiaozhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487131/
https://www.ncbi.nlm.nih.gov/pubmed/36127685
http://dx.doi.org/10.1186/s12891-022-05822-8