Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus

Tricyclic pyrrolopyrimidines (TPPs) are a new class of antibacterials inhibiting the ATPase of DNA gyrase. TPP8, a representative of this class, is active against Mycobacterium abscessus in vitro. Spontaneous TPP8 resistance mutations mapped to the ATPase domain of M. abscessus DNA gyrase, and the c...

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Detalles Bibliográficos
Autores principales: Madani, Abdeldjalil, Negatu, Dereje A., El Marrouni, Abdellatif, Miller, Randy R., Boyce, Christopher W., Murgolo, Nicholas, Bungard, Christopher J., Zimmerman, Matthew D., Dartois, Véronique, Gengenbacher, Martin, Olsen, David B., Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487482/
https://www.ncbi.nlm.nih.gov/pubmed/36005813
http://dx.doi.org/10.1128/aac.00669-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487482/
https://www.ncbi.nlm.nih.gov/pubmed/36005813
http://dx.doi.org/10.1128/aac.00669-22

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