Cargando…

A Novel Leucyl-tRNA Synthetase Inhibitor, MRX-6038, Expresses Anti-Mycobacterium abscessus Activity In Vitro and In Vivo

Therapeutic options for Mycobacterium abscessus infections are extremely limited, and new drugs are needed. The anti-M. abscessus activity of MRX-6038, a new leucyl-tRNA synthetase inhibitor, was evaluated in vitro and in vivo. Antimicrobial susceptibility testing was performed on 12 nontuberculosis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Wenye, He, Siyuan, Li, Anqi, Guo, Qi, Tan, Zhili, Liu, Shicong, Wang, Xinghai, Zhang, Zhemin, Li, Bing, Chu, Haiqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Susceptibility
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487484/ https://www.ncbi.nlm.nih.gov/pubmed/35969055 http://dx.doi.org/10.1128/aac.00601-22

Ejemplares similares

A Novel Oxazolidinone, Contezolid (MRX-I), Expresses Anti-Mycobacterium abscessus Activity In Vitro
por: Guo, Qi, et al.
Publicado: (2021)

2148. In vitro Potency of a Leucyl-tRNA Synthetase Inhibitor, MRX-6038, Against Mycobacterium tuberculosis, Mycobacterium avium, and Mycobacterium abscessus
por: Shoen, Carolyn M, et al.
Publicado: (2023)

Determination of MIC Distribution and Mechanisms of Decreased Susceptibility to Bedaquiline among Clinical Isolates of Mycobacterium abscessus
por: Li, Bing, et al.
Publicado: (2018)

AR-12 Exhibits Direct and Host-Targeted Antibacterial Activity toward Mycobacterium abscessus
por: Zhang, Shaoyan, et al.
Publicado: (2020)

Rifabutin Is Active against Mycobacterium abscessus Complex
por: Aziz, Dinah Binte, et al.
Publicado: (2017)

Vancomycin and Clarithromycin Show Synergy against Mycobacterium abscessus In Vitro
por: Mukherjee, Devika, et al.
Publicado: (2017)

The in vitro effect of new combinations of carbapenem–β-lactamase inhibitors for Mycobacterium abscessus
por: Fröberg, Gabrielle, et al.
Publicado: (2023)

Mycobacterium abscessus Smooth and Rough Morphotypes Form Antimicrobial-Tolerant Biofilm Phenotypes but Are Killed by Acetic Acid
por: Clary, Gillian, et al.
Publicado: (2018)

Sitafloxacin Expresses Potent Anti-Mycobacterium abscessus Activity
por: He, Siyuan, et al.
Publicado: (2022)

Potency of Omadacycline against Mycobacteroides abscessus Clinical Isolates In Vitro and in a Mouse Model of Pulmonary Infection
por: Nicklas, Danielle A., et al.
Publicado: (2022)

Omadacycline, Eravacycline, and Tigecycline Express Anti-Mycobacterium abscessus Activity In Vitro
por: Li, Anqi, et al.
Publicado: (2023)

A Leucyl-tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5′AMP
por: Hobson, Jessica J., et al.
Publicado: (2022)

A human leucyl-tRNA synthetase as an anticancer target
por: Gao, Guangwei, et al.
Publicado: (2015)

Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients
por: Reichmuth, Martina L., et al.
Publicado: (2020)

Phenotypically Adapted Mycobacterium tuberculosis Populations from Sputum Are Tolerant to First-Line Drugs
por: Turapov, Obolbek, et al.
Publicado: (2016)

Developing Synergistic Drug Combinations To Restore Antibiotic Sensitivity in Drug-Resistant Mycobacterium tuberculosis
por: Omollo, Charles, et al.
Publicado: (2021)

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase
por: Palencia, Andrés, et al.
Publicado: (2016)

Rapid, Semiquantitative Assay To Discriminate among Compounds with Activity against Replicating or Nonreplicating Mycobacterium tuberculosis
por: Gold, Ben, et al.
Publicado: (2015)

In Vitro Profiling of Antitubercular Compounds by Rapid, Efficient, and Nondestructive Assays Using Autoluminescent Mycobacterium tuberculosis
por: Shetye, Gauri S., et al.
Publicado: (2021)

A Flow Cytometry Method for Rapidly Assessing Mycobacterium tuberculosis Responses to Antibiotics with Different Modes of Action
por: Hendon-Dunn, Charlotte Louise, et al.
Publicado: (2016)

Regrowth of Mycobacterium tuberculosis Populations Exposed to Antibiotic Combinations Is Due to the Presence of Isoniazid and Not Bacterial Growth Rate
por: Hendon-Dunn, Charlotte L., et al.
Publicado: (2019)

Crucial role of the C-terminal domain of Mycobacterium tuberculosis leucyl-tRNA synthetase in aminoacylation and editing
por: Hu, Qing-Hua, et al.
Publicado: (2013)

Pyrazinamide Susceptibility and pncA Mutation Profiles of Mycobacterium tuberculosis among Multidrug-Resistant Tuberculosis Patients in Bangladesh
por: Rahman, Arfatur, et al.
Publicado: (2017)

Ancient origin of the divergent forms of leucyl-tRNA synthetases in the Halobacteriales
por: Andam, Cheryl P, et al.
Publicado: (2012)

A Diagnostic Algorithm To Investigate Pyrazinamide and Ethambutol Resistance in Rifampin-Resistant Mycobacterium tuberculosis Isolates in a Low-Incidence Setting
por: Andres, Söenke, et al.
Publicado: (2019)

Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis
por: Rancoita, Paola M. V., et al.
Publicado: (2018)

Most-Probable-Number-Based Minimum Duration of Killing Assay for Determining the Spectrum of Rifampicin Susceptibility in Clinical Mycobacterium tuberculosis Isolates
por: Vijay, Srinivasan, et al.
Publicado: (2021)

Antibacterial activity of the novel oxazolidinone contezolid (MRX-I) against Mycobacterium abscessus
por: Gao, Shan., et al.
Publicado: (2023)

Thin-Layer-Agar-Based Direct Phenotypic Drug Susceptibility Testing on Sputum in Eswatini Rapidly Detects Mycobacterium tuberculosis Growth and Rifampicin Resistance Otherwise Missed by WHO-Endorsed Diagnostic Tests
por: Ardizzoni, E., et al.
Publicado: (2021)

Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish
por: Inoue, Masanori, et al.
Publicado: (2021)

A Leucyl-tRNA Synthetase Inhibitor with Broad-Spectrum Antimycobacterial Activity
por: Ganapathy, Uday S., et al.
Publicado: (2021)

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase
por: Palencia, Andrés, et al.
Publicado: (2016)

Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond
por: Liu, Ru-Juan, et al.
Publicado: (2020)

Recognition of tRNA(Leu) by Aquifex aeolicus leucyl-tRNA synthetase during the aminoacylation and editing steps
por: Yao, Peng, et al.
Publicado: (2008)

A Survey of Helicobacter pylori Antibiotic-Resistant Genotypes and Strain Lineages by Whole-Genome Sequencing in China
por: Zhou, Yan, et al.
Publicado: (2022)

Activity of the Novel Aminomethylcycline KBP-7072 and Comparators against 1,057 Geographically Diverse Recent Clinical Isolates from the SENTRY Surveillance Program, 2019
por: Huband, Michael D., et al.
Publicado: (2022)

Potency of Olorofim (F901318) Compared to Contemporary Antifungal Agents against Clinical Aspergillus fumigatus Isolates and Review of Azole Resistance Phenotype and Genotype Epidemiology in China
por: Su, Huilin, et al.
Publicado: (2021)

In Vitro Activity of Ertapenem against Neisseria gonorrhoeae Clinical Isolates with Decreased Susceptibility or Resistance to Extended-Spectrum Cephalosporins in Nanjing, China (2013 to 2019)
por: Li, Xuechun, et al.
Publicado: (2022)

Structural dynamics of the aminoacylation and proof-reading functional cycle of bacterial leucyl-tRNA synthetase
por: Palencia, Andrés, et al.
Publicado: (2012)

Bicarbonate Resensitization of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics
por: Ersoy, Selvi C., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vav809nf79ejcc05q5n86pnl9u