A Novel Oral GyrB/ParE Dual Binding Inhibitor Effective against Multidrug-Resistant Neisseria gonorrhoeae and Other High-Threat Pathogens

Drug-resistant Neisseria gonorrhoeae is a serious global health concern. New drugs are needed that can overcome existing drug resistance and limit the development of new resistances. Here, we describe the small molecule tricyclic pyrimidoindole JSF-2414 [8-(6-fluoro-8-(methylamino)-2-((2-methylpyrim...

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Detalles Bibliográficos
Autores principales: Park, Steven, Russo, Riccardo, Westfall, Landon, Shrestha, Riju, Zimmerman, Matthew, Dartois, Veronique, Kurepina, Natalia, Kreiswirth, Barry, Singleton, Eric, Li, Shao-Gang, Mittal, Nisha, Ahn, Yong-Mo, Bilotta, Joseph, Connolly, Kristie L., Jerse, Ann E., Freundlich, Joel S., Perlin, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487510/
https://www.ncbi.nlm.nih.gov/pubmed/35972242
http://dx.doi.org/10.1128/aac.00414-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487510/
https://www.ncbi.nlm.nih.gov/pubmed/35972242
http://dx.doi.org/10.1128/aac.00414-22

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