Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model

Colchicine (Col) is used to prevent and treat acute gout flare; however, its therapeutic use is strictly limited owing to severe gastrointestinal side effects after oral administration. Therefore, we developed a dissolvable Col-loaded microneedle (MN) with hyaluronic acid to deliver Col via the tran...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Zhu, Xiaoruo, Ji, Shiliang, Huang, Zhen, Zang, Yuhui, Ding, Ying, Zhang, Junfeng, Ding, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487926/
https://www.ncbi.nlm.nih.gov/pubmed/36101018
http://dx.doi.org/10.1080/10717544.2022.2122632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9487926/
https://www.ncbi.nlm.nih.gov/pubmed/36101018
http://dx.doi.org/10.1080/10717544.2022.2122632

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