Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism

The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR ADGRF5/GPR116 have not been completely deciphered. We set out to investigate the physiological importance of autocatalytic cleavage upstream of the agonistic peptide sequence, an event necessary for NTF displace...

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Detalles Bibliográficos
Autores principales: Bridges, James P, Safina, Caterina, Pirard, Bernard, Brown, Kari, Filuta, Alyssa, Panchanathan, Ravichandran, Bouhelal, Rochdi, Reymann, Nicole, Patel, Sejal, Seuwen, Klaus, Miller, William E, Ludwig, Marie-Gabrielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489211/
https://www.ncbi.nlm.nih.gov/pubmed/36073784
http://dx.doi.org/10.7554/eLife.69061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489211/
https://www.ncbi.nlm.nih.gov/pubmed/36073784
http://dx.doi.org/10.7554/eLife.69061

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