Lipopolysaccharide Inhibits Autophagy and Promotes Inflammatory Responses via p38 MAPK-Induced Proteasomal Degradation of Atg13 in Hepatic Stellate Cells

BACKGROUND: Inflammation plays a critical role in the progression of acute-on-chronic liver failure (ACLF). Atg13 is a vital regulatory component of the ULK1 complex, which plays an essential role in the initiation of autophagy. Previously, hepatic stellate cells (HSCs) were considered to be noninfl...

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Detalles Bibliográficos
Autores principales: Wu, Yuchao, He, Yajuan, Wang, Fei, Yao, Naijuan, Zhao, Yingren, Tian, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489415/
https://www.ncbi.nlm.nih.gov/pubmed/36148140
http://dx.doi.org/10.1155/2022/9603989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489415/
https://www.ncbi.nlm.nih.gov/pubmed/36148140
http://dx.doi.org/10.1155/2022/9603989

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