Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development

The serine/threonine protein kinase AKT plays a pivotal role within the PI3K pathway in regulating cellular proliferation and apoptotic cellular functions, and AKT hyper-activation via gene amplification and/or mutation has been implicated in multiple human malignancies. There are 3 AKT isoenzymes (...

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Detalles Bibliográficos
Autores principales: Page, Natalie, Wappett, Mark, O’Dowd, Colin R., O’Rourke, Martin, Gavory, Gerald, Zhang, Lixin, Rountree, J. S. Shane, Jordan, Linda, Barker, Oliver, Gibson, Hayley, Boyd, Caroline, Feutren-Burton, Stephanie, McLean, Estelle, Trevitt, Graham, Harrison, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489722/
https://www.ncbi.nlm.nih.gov/pubmed/36127435
http://dx.doi.org/10.1038/s41598-022-20208-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489722/
https://www.ncbi.nlm.nih.gov/pubmed/36127435
http://dx.doi.org/10.1038/s41598-022-20208-5

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