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Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling

Adhesion G protein-coupled receptors (aGPCRs) are keys of many physiological events and attractive targets for various diseases. aGPCRs are also known to be capable of self-activation via an autoproteolysis process that removes the inhibitory GAIN domain on the extracellular side of receptor and rel...

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Detalles Bibliográficos
Autores principales: Zhu, Xinyan, Qian, Yu, Li, Xiaowan, Xu, Zhenmei, Xia, Ruixue, Wang, Na, Liang, Jiale, Yin, Han, Zhang, Anqi, Guo, Changyou, Wang, Guangfu, He, Yuanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489763/
https://www.ncbi.nlm.nih.gov/pubmed/36127364
http://dx.doi.org/10.1038/s41467-022-33173-4