Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease

Soluble α-synuclein aggregates varying in size, structure, and morphology have been closely linked to neuronal death in Parkinson’s disease. However, the heterogeneity of different co-existing aggregate species makes it hard to isolate and study their individual toxic properties. Here, we show a rel...

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Detalles Bibliográficos
Autores principales: Emin, Derya, Zhang, Yu P., Lobanova, Evgeniia, Miller, Alyssa, Li, Xuecong, Xia, Zengjie, Dakin, Helen, Sideris, Dimitrios I., Lam, Jeff Y. L., Ranasinghe, Rohan T., Kouli, Antonina, Zhao, Yanyan, De, Suman, Knowles, Tuomas P. J., Vendruscolo, Michele, Ruggeri, Francesco S., Aigbirhio, Franklin I., Williams-Gray, Caroline H., Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489799/
https://www.ncbi.nlm.nih.gov/pubmed/36127374
http://dx.doi.org/10.1038/s41467-022-33252-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489799/
https://www.ncbi.nlm.nih.gov/pubmed/36127374
http://dx.doi.org/10.1038/s41467-022-33252-6

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