Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection

Hyperglycaemia at the time of myocardial infarction has an adverse effect on prognosis irrespective of a prior diagnosis of diabetes, suggesting glucose is the damaging factor. In ex vivo models of ischaemia, we demonstrated that deleterious effects of acutely elevated glucose are PKCα/β-dependent,...

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Detalles Bibliográficos
Autores principales: Brennan, Sean, Esposito, Simona, Abdelaziz, Muhammad I. M., Martin, Christopher A., Makwana, Samir, Sims, Mark W., Squire, Iain B., Sharma, Parveen, Chadwick, Amy E., Rainbow, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489859/
https://www.ncbi.nlm.nih.gov/pubmed/36158799
http://dx.doi.org/10.3389/fcvm.2022.997013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489859/
https://www.ncbi.nlm.nih.gov/pubmed/36158799
http://dx.doi.org/10.3389/fcvm.2022.997013

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