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Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection
Hyperglycaemia at the time of myocardial infarction has an adverse effect on prognosis irrespective of a prior diagnosis of diabetes, suggesting glucose is the damaging factor. In ex vivo models of ischaemia, we demonstrated that deleterious effects of acutely elevated glucose are PKCα/β-dependent,...
Autores principales: | Brennan, Sean, Esposito, Simona, Abdelaziz, Muhammad I. M., Martin, Christopher A., Makwana, Samir, Sims, Mark W., Squire, Iain B., Sharma, Parveen, Chadwick, Amy E., Rainbow, Richard D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489859/ https://www.ncbi.nlm.nih.gov/pubmed/36158799 http://dx.doi.org/10.3389/fcvm.2022.997013 |
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