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SGLT2 inhibitors attenuate nephrin loss and enhance TGF-β(1) secretion in type 2 diabetes patients with albuminuria: a randomized clinical trial

To evaluate the effect of SGLT2 inhibitor (SGLT2i) on albuminuria, nephrin (NPH) and transforming-growth-factor-beta(1) (TGF-β1) levels in urine and low-grade inflammation in type 2 diabetes (T2D) patients. A randomized, blank-controlled clinical trial included 68 T2D patients and 10 controls. Based...

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Detalles Bibliográficos
Autores principales: Tian, Yuan, Chen, Xiao-min, Liang, Xian-ming, Wu, Xiao-bin, Yao, Chun-meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9489863/
https://www.ncbi.nlm.nih.gov/pubmed/36127497
http://dx.doi.org/10.1038/s41598-022-19988-7