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Diffusion of small molecule drugs is affected by surface interactions and crowder proteins

Crowded environments are known to affect the diffusion of macromolecules, but their effects on the diffusion of small molecules are largely uncharacterized. We investigate how three protein crowders, bovine serum albumin (BSA), hen egg-white lysozyme, and myoglobin, influence the diffusion rates and...

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Detalles Bibliográficos
Autores principales: Dey, Debabrata, Nunes-Alves, Ariane, Wade, Rebecca C., Schreiber, Gideon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490042/
https://www.ncbi.nlm.nih.gov/pubmed/36157590
http://dx.doi.org/10.1016/j.isci.2022.105088