Impaired Cdc20 signaling promotes senescence in normal cells and apoptosis in non–small cell lung cancer cells

Cellular senescence is a form of irreversible growth arrest that cancer cells evade. The cell division cycle protein 20 homolog (Cdc20) is a positive regulator of cell division, but how its dysregulation may relate to senescence is unclear. Here, we find that Cdc20 mRNA and protein expression are do...

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Detalles Bibliográficos
Autores principales: Volonte, Daniela, Sedorovitz, Morgan, Galbiati, Ferruccio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490043/
https://www.ncbi.nlm.nih.gov/pubmed/35988650
http://dx.doi.org/10.1016/j.jbc.2022.102405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490043/
https://www.ncbi.nlm.nih.gov/pubmed/35988650
http://dx.doi.org/10.1016/j.jbc.2022.102405

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