Synthesis and evaluation of anticancer activity of quillaic acid derivatives: A cell cycle arrest and apoptosis inducer through NF-κB and MAPK pathways

A series of quillaic acid derivatives with different substituents on the 28-carboxyl group were designed and synthesized. Five human cancer cell lines (HCT116, BEL7402, HepG2, SW620, and MCF-7) were evaluated for their antitumor activity in vitro. Some of the tested derivatives showed improved antip...

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Detalles Bibliográficos
Autores principales: Huang, Xing, Zhang, Chang-Hao, Deng, Hao, Wu, Dan, Guo, Hong-Yan, Lee, Jung Joon, Chen, Fen-Er, Shen, Qing-Kun, Jin, Li-Li, Quan, Zhe-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490060/
https://www.ncbi.nlm.nih.gov/pubmed/36157038
http://dx.doi.org/10.3389/fchem.2022.951713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490060/
https://www.ncbi.nlm.nih.gov/pubmed/36157038
http://dx.doi.org/10.3389/fchem.2022.951713

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