Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells

Tyrosine kinase inhibitors (TKIs) are frequently used in combined therapy to enhance treatment efficacy and overcome drug resistance. The present study analyzed the effects of three inhibitors, sunitinib, gefitinib, and lapatinib, combined with iron-chelating agents, di-2-pyridylketone-4,4-dimethyl-...

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Detalles Bibliográficos
Autores principales: Krchniakova, Maria, Paukovcekova, Silvia, Chlapek, Petr, Neradil, Jakub, Skoda, Jan, Veselska, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490180/
https://www.ncbi.nlm.nih.gov/pubmed/36160437
http://dx.doi.org/10.3389/fphar.2022.976955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490180/
https://www.ncbi.nlm.nih.gov/pubmed/36160437
http://dx.doi.org/10.3389/fphar.2022.976955

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