A direct comparison between AML1-ETO and ETO2-GLIS2 leukemia fusion proteins reveals context-dependent binding and regulation of target genes and opposite functions in cell differentiation

The ETO-family transcriptional corepressors, including ETO, ETO2, and MTGR1, are all involved in leukemia-causing chromosomal translocations. In every case, an ETO-family corepressor acquires a DNA-binding domain (DBD) to form a typical transcription factor—the DBD binds to DNA, while the ETO moiety...

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Detalles Bibliográficos
Autores principales: Zhang, Yi-Fan, Wang, Xiao-Lin, Xu, Chun-Hui, Liu, Na, Zhang, Ling, Zhang, Yu-Ming, Xie, Yin-Yin, Zhang, Yuan-Liang, Huang, Qiu-Hua, Wang, Lan, Chen, Zhu, Chen, Sai-Juan, Roeder, Robert G., Shen, Shuhong, Xue, Kai, Sun, Xiao-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490184/
https://www.ncbi.nlm.nih.gov/pubmed/36158200
http://dx.doi.org/10.3389/fcell.2022.992714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490184/
https://www.ncbi.nlm.nih.gov/pubmed/36158200
http://dx.doi.org/10.3389/fcell.2022.992714

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