Monoclonal anti-endoglin antibody TRC105 (carotuximab) prevents hypercholesterolemia and hyperglycemia-induced endothelial dysfunction in human aortic endothelial cells

Endoglin (Eng) is a co-receptor of the transforming growth factor β superfamily playing an important role in endothelial dysfunction. TRC105 (carotuximab) is a monoclonal antibody that blocks Eng and its downstream Smad signaling pathway. Here we have investigated for the first time the effects of T...

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Detalles Bibliográficos
Autores principales: Tripska, Katarina, Igreja Sá, Ivone Cristina, Vasinova, Martina, Vicen, Matej, Havelek, Radim, Eissazadeh, Samira, Svobodova, Zuzana, Vitverova, Barbora, Theuer, Charles, Bernabeu, Carmelo, Nachtigal, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490272/
https://www.ncbi.nlm.nih.gov/pubmed/36160139
http://dx.doi.org/10.3389/fmed.2022.845918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490272/
https://www.ncbi.nlm.nih.gov/pubmed/36160139
http://dx.doi.org/10.3389/fmed.2022.845918

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