Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1

In humans, a single enzyme 2-aminoadipic semialdehyde synthase (AASS) catalyses the initial two critical reactions in the lysine degradation pathway. This enzyme evolved to be a bifunctional enzyme with both lysine-2-oxoglutarate reductase (LOR) and saccharopine dehydrogenase domains (SDH). Moreover...

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Detalles Bibliográficos
Autores principales: Leandro, João, Khamrui, Susmita, Suebsuwong, Chalada, Chen, Peng-Jen, Secor, Cody, Dodatko, Tetyana, Yu, Chunli, Sanchez, Roberto, DeVita, Robert J., Houten, Sander M., Lazarus, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490328/
https://www.ncbi.nlm.nih.gov/pubmed/36128717
http://dx.doi.org/10.1098/rsob.220179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490328/
https://www.ncbi.nlm.nih.gov/pubmed/36128717
http://dx.doi.org/10.1098/rsob.220179

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