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From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs

Senescence is a cellular stress response that involves prolonged cell survival, a quasi-irreversible proliferative arrest and a modification of the transcriptome that sometimes includes inflammatory gene expression. Senescent cells are resistant to apoptosis, and if not eliminated by the immune syst...

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Detalles Bibliográficos
Autores principales: L'Hôte, Valentin, Mann, Carl, Thuret, Jean-Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490338/
https://www.ncbi.nlm.nih.gov/pubmed/36128715
http://dx.doi.org/10.1098/rsob.220171