Antagonism Between DUX4 and DUX4c Highlights a Pathomechanism Operating Through β-Catenin in Facioscapulohumeral Muscular Dystrophy

Aberrant expression of the transcription factor DUX4 from D4Z4 macrosatellite repeats on chromosome 4q35, and its transcriptome, associate with pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). Forced DUX4 expression halts skeletal muscle cell proliferation and induces cell death. DUX4...

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Detalles Bibliográficos
Autores principales: Ganassi, Massimo, Figeac, Nicolas, Reynaud, Magalie, Ortuste Quiroga, Huascar Pedro, Zammit, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490378/
https://www.ncbi.nlm.nih.gov/pubmed/36158201
http://dx.doi.org/10.3389/fcell.2022.802573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490378/
https://www.ncbi.nlm.nih.gov/pubmed/36158201
http://dx.doi.org/10.3389/fcell.2022.802573

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